Nature：辐射影响基因表达

情况和医学仪器都可能给人类带来辐射。辐射的成果会导致细胞内的遗传物资受到损坏或毁伤，为应对这些放射性毁伤，细胞内的复合物平日经由过程转变基因表达情形来顺应新的变更。然而，每个个别对辐射性毁伤的应答处置有可能分歧，具体情形因人而异。

在本研讨中，研讨团队判定出一种应对辐射毁伤的基因表达调控器。研讨小组用辐射引诱基因表达程度产生转变，同时对这些转变做出定量的检测，并研讨基因连锁反响，追踪基因表达调控器的运动情形。成果发明染色体的特定区域与1200例辐射毁伤的基因表达有联系关系。基因表达调控器以反式感化的方法影响基因表达程度，很少是顺式调节器。有些反式调控器起转录因子样的感化。

这些结果对辐射影响基因表达研讨具有主要的指点感化，为辐射遗传学说的理论研讨开拓了新的视野。

原文检索：Genetic analysis of radiation-induced changes in human gene expression

Humans are exposed to radiation through the environment and in medical settings. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. These gene expression responses differ greatly between individuals1 and contribute to individual differences in response to radiation2. Here we identify regulators that influence expression levels of radiation-responsive genes. We treated radiation-induced changes in gene expression as quantitative phenotypes3, 4, and conducted genetic linkage and association studies to map their regulators. For more than 1,200 of these phenotypes there was significant evidence of linkage to specific chromosomal regions. Nearly all of the regulators act in trans to influence the expression of their target genes; there are very few cis-acting regulators. Some of the trans-acting regulators are transcription factors, but others are genes that were not known to have a regulatory function in radiation response. These results have implications for our basic and clinical understanding of how human cells respond to radiation.